Midlife Fitness, Incident Cancer, and Survival After Cancer in Men
The study found that higher levels of midlife cardiorespiratory fitness provide a mortality benefit into older age even in the setting of a cancer diagnosis.
Lakoski, Susan G. et al. (2015). Midlife Cardiorespiratory Fitness, Incident Cancer, and Survival After Cancer in Men: the Cooper Center longitudinal study. JAMA Oncology. doi:10.1001/jamaoncol.2015.0226
To assess the association between midlife CRF and incident cancer and survival following a cancer diagnosis.
Compared with men with low CRF, the adjusted hazard ratios (HRs) for incident lung, colorectal, and prostate cancers among men with high CRF were 0.45 (95% CI, 0.29-0.68), 0.56 (95% CI, 0.36-0.87), and 1.22 (95% CI, 1.02-1.46), respectively. Among those diagnosed as having cancer at Medicare age, high CRF in midlife was associated with an adjusted 32% (HR, 0.68; 95% CI, 0.47-0.98) risk reduction in all cancer-related deaths and a 68% reduction in cardiovascular disease mortality following a cancer diagnosis (HR, 0.32; 95% CI, 0.16-0.64) compared with men with low CRF in midlife.
There is an inverse association between midlife CRF and incident lung and colorectal cancer but not prostate cancer. High midlife CRF is associated with lower risk of cause-specific mortality in those diagnosed as having cancer at Medicare age.